解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::A syngeneic tumor system in DBA/2 mice consisting of a methyl-cholanthrene-induced, weakly metastatic lymphoma, L5178YE (= Eb), its spontaneous strongly metastatic variant, L5178YES (= ESb), and an unrelated, methylcholanthrene-induced, metastasizing tumor, MDAY-D2, were used to study the relationship between metastat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360514
更新日期:1985-11-15 00:00:00
abstract::Monoclonal antibody 38.13 was raised against the Burkitt lymphoma cell line Daudi and has been previously shown to recognize a globotriaosylceramide (Pk) determinant expressed selectively on Burkitt and a few other B-cell lymphomas. We report here that 38.13 binds to a subset of normal B lymphocytes in germinal centre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360508
更新日期:1985-11-15 00:00:00
abstract::Using morphometric and immunohistological techniques, we investigated the distribution of T lymphocytes and subsets, B lymphocytes, macrophages and plasma cells in sections of human breast tissue. In normal lobules and ducts, leukocytes were found in greater density in the epithelium than in the stroma. The intra-epit...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360404
更新日期:1985-10-15 00:00:00
abstract::Cholera toxin (which increases intracellular cAMP levels) significantly (p less than 0.05) increased the growth of MCF-7, T47-D and Hs578T human breast carcinoma cells in vitro. The effect of cholera toxin on growth of MCF-7 and T47-D cells was more pronounced in the presence of 17 beta-estradiol (p less than 0.05), i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360411
更新日期:1985-10-15 00:00:00
abstract::During natural metastasis, cancer cells are released continuously into the bloodstream and arrested in target organs; the process is repetitive rather than a single event. In this communication, the effect of preceding on successive "pulses" of cancer cells is discussed in relation to the arrest, retention and tumor f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360417
更新日期:1985-10-15 00:00:00
abstract::The antiproliferative effect of 2',5' A3 core and 2',5'-3'dA3 (cordycepin trimer) core was measured in 8 human tumor cell lines. Cells were treated in a dose-response manner for 72 hr and the concentration of drug necessary to inhibit cell growth 50% (GI50) was determined. A wide range of sensitivities to these drugs ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:1985-09-15 00:00:00
abstract::Cloned lines from 4 different families of B-16 melanoma cells were heated repeatedly in tissue culture at 45 degrees C with step-up time intervals. These lines included the partially heat-resistant lines previously selected at 43 degrees C(HR 43 degrees) from wheat-germ-agglutinin-resistant mutant (WGAR, HR43 degrees)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:1985-09-15 00:00:00
abstract::The age-standardized mortality rates for malignant melanoma of the skin in immigrants to New Zealand were compared with those of New Zealand-born non-Maoris. Immigrants from European countries had mortality rates that were generally similar to those prevailing in their countries of origin, although, among immigrants f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360208
更新日期:1985-08-15 00:00:00
abstract::The results of a survey of a population with a high incidence of oral and oesophageal cancer are presented. The population under study appears to have several epidemiologic characteristics, some of which may be associated with a high incidence of oral and oesophageal cancer. A remarkably high proportion (41%) of the m...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360205
更新日期:1985-08-15 00:00:00
abstract::Two distinct cell lines (OPM-1 and OPM-2) were established from the peripheral blood of a 56-year-old female myeloma patient at the stage of terminal leukemic evolution associated with loss of cytoplasmic immunoglobulin heavy chain (G lambda----lambda). The lines grew in suspension with a doubling time of 36-42 hr and...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360217
更新日期:1985-08-15 00:00:00
abstract::A human tumor clonogenic assay has been used to test the antiproliferative effect of recombinant human leukocyte interferon alpha 2 alone and in combination with each of 8 cytotoxic agents. Cell lines derived from 6 human tumors and primary tumor cells from 13 patients have been used in these clonogenic assay studies....
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350605
更新日期:1985-06-15 00:00:00
abstract::Breast carcinomas were examined by the immunoperoxidase technique using antisera specific for lymphocyte subsets, monocytes, NK cells and major histocompatibility antigens (HLA-A, -B, -C; Ia-like). Sixty-four per cent of the patients had a moderate or strong mononuclear cell infiltration, 77% of the patients without m...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350610
更新日期:1985-06-15 00:00:00
abstract::The antigen K-1-2, detectable by a MAb is found in nevi and melanomas. It is associated with melanoma cells of low invasive and metastatic potential as shown by immunoperoxidase studies with cell lines, biopsies and autopsies: K-1-2 occurs in melanoma cell line SK-Mel 25, but not in cell line A-375. A-375 has a higher...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350615
更新日期:1985-06-15 00:00:00
abstract::A study was conducted in northern Iran in areas of very high, high and moderately low incidence of oesophageal cancer. Morphine metabolites in urine as an indicator of opium use, and a variety of nutritional and biochemical measures, including salivary antipyrine half-life, were determined in households with a case of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350505
更新日期:1985-05-15 00:00:00
abstract::Six distinct cell surface antigens of human trophoblast and choriocarcinoma were defined with MAbs. The distribution of the antigens was determined by MHA assays on 150 tumor cell lines and normal cell cultures and by immunofluorescence tests with a wide range of normal adult and fetal tissues and a tumor panel. Antig...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350409
更新日期:1985-04-15 00:00:00
abstract::The distribution of oestradiol in plasma from postmenopausal women with or without breast cancer has been measured and related to the metabolic clearance rates of oestradiol (MCR-E2). All measurements were carried out preoperatively. No difference in the free fraction of oestradiol was found between women with breast ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350407
更新日期:1985-04-15 00:00:00
abstract::The growth of 7/9 Burkitt's lymphoma (BL) cell lines and 5/6 human melanoma cell lines was inhibited by certain human fibroblast-like cell lines, especially human myofibroblast cell lines. In contrast to BL lines, 3/5 lymphoblastoid cell lines were less susceptible and 3/4 human leukaemic lines were resistant. The eff...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350410
更新日期:1985-04-15 00:00:00
abstract::Using antisera for two specific basement membrane (b.m.) antigens such as laminin and collagen type-IV, together with electron microscopy, we have shown that fully antigenic b.m. and morphologically typical basal lamina (b.l.) are associated with normal and transformed cells of the melanocyte lineage in different ways...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350408
更新日期:1985-04-15 00:00:00
abstract::Spontaneous tumor development and primary oncogenesis were compared in a large number of NK4-deficient, homozygous C57Bl/6-bg/bg mice and their NK normal, heterozygous +/bg littermate controls. In a group of 167 retired breeders followed for spontaneous tumors, the probability of survival for mice eventually dying wit...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350414
更新日期:1985-04-15 00:00:00
abstract::Polyclonal and monoclonal antibodies were used to characterize human milk fat globule (HMFG) membrane antigens, using gel filtration, ion exchange chromatography and western blotting. Although originally generated against HMFG, monoclonal antibodies also reacted with skim milk. In western blotting, several antigen mol...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350207
更新日期:1985-02-15 00:00:00
abstract::In the past, it has been impossible to carry out immunohistological staining as part of a rapid histopathological diagnosis during surgery because the available methods were too time-consuming. The present report introduces a rapid indirect immunoperoxidase method that requires only 10-12 min. Thus, the immunological ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350205
更新日期:1985-02-15 00:00:00
abstract::We have studied the clonal heterogeneity of 2 spontaneously metastasizing mammary carcinomas which recently arose spontaneously in C3H/He female retired breeders. Cells of early (2nd to 5th) transplant generations of these tumors were cloned by a combination of semi-solid agarose colony formation and limiting dilution...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350220
更新日期:1985-02-15 00:00:00
abstract::The secretion of antibody by hybridoma cells allows the growth of individual cells to be measured by a hemolytic plaque assay. Similarly, plaque reduction assays were sensitive indicators of tumor immunity. A series of strains of hybridoma have been isolated from an original isolate which is sensitive to cytotoxic T c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350117
更新日期:1985-01-15 00:00:00
abstract::A panel of 24 healthy seropositive donors have been followed prospectively over a period of 15 months and monitored (1) for the level of EB virus shedding in the throat by means of a sensitive cord-blood transformation assay; (2) for the level of virus-infected B cells in the blood via a new in vitro protocol where "s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350107
更新日期:1985-01-15 00:00:00
abstract::A study was made on the effect of ovariectomy, 17 beta-oestradiol, and tamoxifen on the oestrogen and progesterone receptor-positive T61 human breast carcinoma grown in nude mice. The effect of the treatment was evaluated by the specific growth delay calculated on the basis of Gompertz growth curves, and by the change...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350110
更新日期:1985-01-15 00:00:00
abstract::Highly differentiated, spontaneous hepatomas occurring in 13- to 15-month-old CBA mice were unable to produce embryo-specific serum protein alpha-fetoprotein (AFP). AFP synthesis, however, was induced in such tumors by minimal mechanical damage (small incisions of the tumors). On the 3rd day following surgery, AFP-pos...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350121
更新日期:1985-01-15 00:00:00
abstract::The effects of the tumor promoter -12-O-tetradecanoyl phorbol-13-acetate, its analogues, and other tumor promoters, on the proliferation of human skin fibroblasts (SF) have been investigated. We have previously shown (Kopelovich and Bias, 1979), that TPA caused a biphasic (upward concave) dose effect in the cloning ef...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340608
更新日期:1984-12-15 00:00:00
abstract::A case-control study of 374 patients with primary epithelial cancers of the oral cavity, oro- and hypopharynx, and larynx is reported, the controls being patients with selected other cancers, matched for age and sex. Of all eligible patients, 93% were interviewed. Increased risks were seen with alcohol consumption and...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340504
更新日期:1984-11-15 00:00:00
abstract::The stability of expression of a membrane antigen on human FME melanoma cells was investigated by means of flow cytometric cell sorting and analysis. The melanoma-associated 250 kd antigen was strongly expressed on all cells, as recognized by binding of the monoclonal antibody 9.2.27. By flow cytometric cell sorting, ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340413
更新日期:1984-10-15 00:00:00
abstract::The expression of a gastrointestinal carcinoma-associated antigen (GICA), a monosialoganglioside, was investigated in tissues from human fetuses of various gestational ages (10-40 weeks). Mouse monoclonal antibody NS-19-9, generated in mice immunized with SW1116 human colon carcinoma cells, was used along with a secon...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340208
更新日期:1984-08-15 00:00:00
abstract::The antitumor activity of highly purified tumor necrosis factor (TNF) was tested against eight kinds of murine tumor and five kinds of human tumor heterotransplanted into nude mice. Mice were treated by intravenous or intratumoral injection of TNF, commencing when the tumors were well established. TNF showed an excell...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340219
更新日期:1984-08-15 00:00:00
abstract::This study reports the induction of interferon (IFN) in human mononuclear cells (MNC) by hematopoietic tumor cells. Only 3 out of 15 cell lines were capable of inducing IFN in the mixed leukocyte/tumor-cell reaction (MLTR). K562, a pluripotent stem cell line and DUTKO-I, a hybrid between K562 and Daudi (Burkitt lympho...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340108
更新日期:1984-07-15 00:00:00
abstract::Subcellular distribution of hexokinase (HK) isoenzymes in 22 human breast cancers (21 primary cancers and 1 axillary metastatic growth) and 7 non-pathological human mammary gland tissue samples was studied with starch gel electrophoresis on isolated cell fractions obtained by differential centrifugation. Fractions use...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340111
更新日期:1984-07-15 00:00:00
abstract::The effects of long-term treatment with mouse interferon on the phenotype of untransformed C3H/10T1/2 cells and cloned derivatives transformed by methylcholanthrene (MCA) and Simian virus 40 (SV40) were investigated. Continuous presence of interferon induced morphologic reversion, with the development of thick, submem...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340119
更新日期:1984-07-15 00:00:00
abstract::A panel of conventional and monoclonal antibodies was used to examine the immunohistological characteristics of malignant epithelial cells and infiltrating lymphocytes in frozen sections of nasopharyngeal carcinoma (NPC) biopsies from 10 Tunisian patients. Three main categories of cells were identified. (1) Tumour cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330616
更新日期:1984-06-15 00:00:00
abstract::Somatic cell hybrids have been made between a transformed mouse bladder carcinoma cell line and normal mouse bladder epithelium and mesenchyme. In the epithelial tumour/mesenchyme hybrids the malignant phenotype was expressed dominantly whereas in the carcinoma/normal epithelium hybrids the malignant potential was gre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330517
更新日期:1984-05-15 00:00:00
abstract::In order to examine the role of cell surface laminin in tumor metastasis we have utilized four well-characterized murine fibrosarcoma cell lines. Two of these lines were highly metastatic when injected into syngeneic mice while the remaining two lines were significantly less metastatic. Using indirect immunofluorescen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330516
更新日期:1984-05-15 00:00:00
abstract::Arrest and lodgement of circulating tumor cells in the microvasculature is a prerequisite for metastasis formation. Aggregation of activated platelets and subsequent release of bioactive substances seem to influence the lodgement process. Since thrombocytopenia has been shown to reduce lodgement and since 5-HT is one ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330416
更新日期:1984-04-15 00:00:00
abstract::As many patients with mammary carcinoma are now treated by conservative forms of surgery, there is a need for prognostic information obtainable from the primary tumour alone. One possible source is the antigenic profile of tumour cells. Using an indirect immunoperoxidase technique, we stained histological sections of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330304
更新日期:1984-03-15 00:00:00
abstract::To find out whether manipulation of H-2 expression on metastatic cells could alter their metastatic properties, we immunoselected in vivo H-2 antigen variants from a metastatic clone of the T10 sarcoma [originating in a (C57BL/6J X C3H.eB)FI mouse] and tested their metastatic capacity. The unselected metastatic cells ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330320
更新日期:1984-03-15 00:00:00